According to a study published in the journal Nutrition and Cancer, grape seeds are rich in bioflavonoid compounds known as prosianidin. The compound is also found in apples and chocolate is said to be efficient in killing prostate cancer cells.
However, the researchers do not yet know the specific compound most responsible for the process. In the new study, the researchers only shows in detail how to synthesize compounds in grape seeds can kill cancer cells.
The study researchers from the University of Colorado Cancer Center said, prosianidin compound that is naturally found in grape seeds, is a complex mixture of polyphenols.
“So far it is not clear how the compound can fight cancer cells,” said Alpna Tyagi, one of the study researchers from the University of Colorado Skaggs School of Pharmacy and phamaceutical Science.
The researchers found, prosianidin B2G2 the most active compounds against cancer cells. But to get it, it takes grape seed in very much, and the process is complicated and costly isolation. Then makes these compounds in synthetic form are considered the most good.
Tests on prostate cancer cells showed that these compounds can inhibit cell growth. In addition, the compounds also trigger cancer cells to commit “suicide” or known as apoptosis.
“Our goal was to test the efficacy of grape seed to the clinical level, but it is still difficult to obtain a permit while not know the mechanism,” said Tyagi.
In addition to prostate cancer, prosiadinin in grape seed extract is also known to have other health benefits. According to the National Institutes of Health, grape seed extract can relieve chronic venous insufficiency, making blood circulation more smoothly from the legs to the heart, and prevent eye problems due to diabetes and blood vessels.